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  • 產(chǎn)品名稱：NAVA 抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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NAVA 抗原（重組蛋白）一直視質(zhì)量控制為企業(yè)的生命，追求企業(yè)競爭力的不斷提升，始終秉承信譽為生存之本的宗旨，以過硬的質(zhì)量和優(yōu)良的服務(wù)來維護和拓展市場，*大限度的滿足客戶的需求，與客戶共贏，是我們的發(fā)展目標，愿與您精誠合作，共創(chuàng)美好的未來。
詳情介紹：



中文名稱： NAVA 抗原（重組蛋白）

英文名稱： INAVA Antigen (Recombinant Protein)

別     名： i nnate immunity activator; C1orf106

儲     存：  冷凍（-20℃）  

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to a region derived from 464-663 amino acids of human INAVA

技術(shù)規(guī)格

Full name:

innate immunity activator

Synonyms:

C1orf106

Swissprot:

Q3KP66

Gene Accession:

BC106877

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).






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