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  • 產(chǎn)品名稱：LATS1抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
LATS1抗原（重組蛋白）科研研究已進(jìn)入全新時(shí)代，愛(ài)好生物研究的學(xué)者越來(lái)越多。不管你是花幾百還是上千，甚至上萬(wàn)去購(gòu)置試劑，這都是*簡(jiǎn)單的**步。你之后需要付出更多的是大量的時(shí)間和精力，再加上你的耐心和用心，才能把這條路走的更遠(yuǎn)。
詳情介紹：

中文名稱：  LATS1抗原（重組蛋白）

英文名稱：  LATS1 Antigen (Recombinant Protein)

別     名：   wts; WARTS

儲(chǔ)     存：   冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Full length fusion protein

技術(shù)規(guī)格

Full name:

large tumor suppressor kinase 1

Synonyms:

wts; WARTS

Swissprot:

O95835

Gene Accession:

BC015665

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.





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