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  • 產(chǎn)品名稱：DDIT4L抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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詳情介紹：


中文名稱： DDIT4L抗原（重組蛋白）

英文名稱： DDIT4L Antigen (Recombinant Protein)

別     名：  REDD2; Rtp801L

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概    述

Full length fusion protein

技術(shù)規(guī)格

Full name:

DNA-damage-inducible transcript 4-like

Synonyms:

REDD2; Rtp801L

Swissprot:

Q96D03

Gene Accession:

BC013592

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.






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