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  • 產(chǎn)品名稱：VDR 抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：100ug
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：800
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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詳情介紹：

中文名稱： VDR 抗原（重組蛋白）

英文名稱： VDR Antigen (Recombinant Protein)

別     名：  vitamin D (1,25- dihydroxyvitamin D3) receptor; NR1I1; PPP1R163

儲(chǔ)     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述：

Fusion protein corresponding to a region derived from 192-427 amino acids of human VDR
    
技術(shù)規(guī)格

Full name:

vitamin D (1,25- dihydroxyvitamin D3) receptor

Synonyms:

NR1I1; PPP1R163

Swissprot:

P11473

Gene Accession:

BC060832

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.





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