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  • 產(chǎn)品名稱：SETD7抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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中文名稱： SETD7抗原（重組蛋白）

英文名稱： SETD7 Antigen (Recombinant Protein)

別     名：  KMT7; SET7; SET9; SET7/9

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述：

Fusion protein corresponding to C terminal 250 amino acids of human SETD7

技術(shù)規(guī)格

Full name:

SET domain containing (lysine methyltransferase) 7

Synonyms:

KMT7; SET7; SET9; SET7/9

Swissprot:

Q8WTS6

Gene Accession:

BC121055

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule in an unusual conformation binds, a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue.







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