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  • 產(chǎn)品名稱：PRKAA2 抗原（重組蛋白）

  • 產(chǎn)品型號：100ug
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：800
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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詳情介紹：
中文名稱： PRKAA2 抗原（重組蛋白）

英文名稱： PRKAA2 Antigen (Recombinant Protein)

別     名：  protein kinase, AMP-activated, alpha 2 catalytic subunit; AMPK; AMPK2; PRKAA; AMPKa2

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述：
  
Fusion protein corresponding to a region derived from 16-268 amino acids of human PRKAA2
   
技術規(guī)格

Full name:

protein kinase, AMP-activated, alpha 2 catalytic subunit

Synonyms:

AMPK; AMPK2; PRKAA; AMPKa2

Swissprot:

P54646

Gene Accession:

BC069680

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.





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