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  • 產(chǎn)品名稱：ERCC6L抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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簡單介紹：
ERCC6L抗原（重組蛋白）公司秉承“專注品質(zhì)、信守承諾、積極溝通、chuang新服務(wù)”的企業(yè)文化積極參與生物領(lǐng)域的技術(shù)chuang新和技術(shù)服務(wù)，力求為我國科研事業(yè)添磚加瓦，嚴(yán)格的質(zhì)控體系，建立和完善企業(yè)制度，創(chuàng)造性發(fā)展，客戶的滿意就是我們的宗旨。
詳情介紹：
中文名稱： ERCC6L抗原（重組蛋白）

英文名稱： ERCC6L Antigen (Recombinant Protein)

別     名：  PICH; RAD26L

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述：

Fusion protein corresponding to C terminal 250 amino acids of human ERCC6L

技術(shù)規(guī)格

Full name:

excision repair cross-complementation group 6-like

Synonyms:

PICH; RAD26L

Swissprot:

Q2NKX8

Gene Accession:

BC008808

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.





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