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  • 產品名稱：BRCC3抗原（重組蛋白）

  • 產品型號：100 ug
  • 產品廠商：通蔚生物
  • 產品價格：800
  • 產品庫存：35
  • 產品文檔：
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簡單介紹：
BRCC3抗原（重組蛋白）自成立以來，就注重企業(yè)信息化的建設，主要用于科研實驗使用，采用了先進的內部供應鏈信息處理平臺，保證客戶訂單的準確、高效處理，客戶關系的管理系統(tǒng)和客戶關系管理團隊，能時間響應客戶的售前、售后需求。
詳情介紹：
中文名稱： BRCC3抗原（重組蛋白）

英文名稱： BRCC3 Antigen (Recombinant Protein)

別     名：  C6.1A; BRCC36; CXorf53

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述：

Fusion protein corresponding to a region derived from 21-316 amino acids of human BRCC3

技術規(guī)格

Full name:

BRCA1/BRCA2-containing complex subunit 3

Synonyms:

C6.1A; BRCC36; CXorf53

Swissprot:

P46736

Gene Accession:

BC002999

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.





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