儲 存: 冷凍(-20℃)
概 述:
Full name: |
Cdc42 guanine nucleotide exchange factor (GEF) |
Synonyms: |
PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN |
Swissprot: |
O43307 |
Gene Accession: |
BC117406 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene. |
