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  • 產(chǎn)品名稱：ALS2 抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
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詳情介紹：


中文名稱： ALS2 抗原（重組蛋白）

英文名稱： ALS2 Antigen (Recombinant Protein)

別     名：  amyotrophic lateral sclerosis 2 (juvenile); ALSJ; PLSJ; IAHSP; ALS2CR6

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述：

Fusion protein corresponding to C terminal 250 amino acids of human ALS2
    
技術(shù)規(guī)格

Full name:

amyotrophic lateral sclerosis 2 (juvenile)

Synonyms:

ALSJ; PLSJ; IAHSP; ALS2CR6

Swissprot:

Q96Q42

Gene Accession:

BC029174

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.






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