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  • 產(chǎn)品名稱：兔抗RCOR1多克隆抗體

  • 產(chǎn)品型號：100ul
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：1560
  • 產(chǎn)品庫存：60
  • 產(chǎn)品文檔：
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詳情介紹：
中文名稱： 兔抗RCOR1多克隆抗體 

英文名稱： Anti-RCOR1 rabbit polyclonal antibody

別      名： REST corepressor 1; RCOR; COREST

相關(guān)類別： 一抗

抗      原： RCOR1

儲      存： 冷凍（-20℃）

宿      主： Rabbit

反應(yīng)種屬： Human, Mouse

標(biāo) 記 物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Applications:

ELISA, WB, IHC

Name of antibody:

RCOR1

Immunogen:

Synthetic peptide of human RCOR1

Full name:

REST corepressor 1

Synonyms:

RCOR; COREST

SwissProt:

Q9UKL0

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer and human lung cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

A431,231 and PC-3 cell lysates

WB Recommended dilution:

200-1000





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