別 名: PVS; HVED; CD155; NECL5; TAGE4; Necl-5
概 述:
Full name: |
poliovirus receptor |
Synonyms: |
PVS; HVED; CD155; NECL5; TAGE4; Necl-5 |
Swissprot: |
P15151 |
Gene Accession: |
BC015542 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. |
